Charité Research Organisation has performed First Time in Human, Phase I and POC studies in a number of dermatological indications. Notably this has included studies in mild-moderate psoriasis, moderate-severe psoriasis and atopic dermatitis.
Studies undertaken have included First Time in Human studies combining dosing in healthy volunteers and dermatology patients. Other Phase I studies undertaken have involved dosing two distinct patient populations in one protocol (RA and psoriasis patients). Internal expertise and capabilities (such as skin biopsy) are complemented by collaboration with the Charité Departments for Dermatology, Venerology and Allergology. Internally and via this collaboration, a full range of assessments and challenge tests are possible, including MED testing, tape stripping and TEWL.